If you have type 2 diabetes, you can choose a similar SGLT2 inhibitor to Jardiance, such as Invokana (canagliflozin). Because both drugs stop a protein that reabsorbs glucose into your kidneys, you’ll experience similar dehydrating side effects with Invokana. You’re also still at risk for ketoacidosis and low blood sugar if you choose Invokana.
Invokana has some different side effects that you won’t see if you take Jardiance. You could experience mineral depletion while taking Invokana, particularly potassium and magnesium. This could result in more bone fractures. Jardiance could cause joint pain or respiratory tract infections. If you have cardiovascular disease and type 2 diabetes, Jardiance can reduce your risk of cardiovascular death, while Invokana cannot. On the other hand, Invokana can reduce your risk of end-stage kidney disease and other conditions if you have both type 2 diabetes and diabetic nephropathy (per SingleCare).
In terms of cost, Invokana also doesn’t have a generic option, which means you’ll be paying about the same price for this drug if you don’t have insurance. Some commercial insurers and Medicare Part D plans don’t cover Invokana.