You should avoid taking ibuprofen if you’re on blood pressure-lowering medications such as angiotensin-converting enzyme (ACE) inhibitors or beta-blockers. ACE inhibitors, such as Lotensin, Capoten, Vasotec, Zestril, and Monopril, work by relaxing and widening blood vessels, thereby enhancing blood flow and reducing blood pressure (via Healthline). However, their effectiveness may be compromised when taken alongside pain relievers like ibuprofen. Per Drugs.com, the combination of these medications can not only decrease the blood pressure-lowering effects of ACE inhibitors but also potentially impact kidney function, particularly with frequent or chronic use. If you notice symptoms like nausea, vomiting, changes in urination patterns, weight fluctuations, fluid retention, swelling, shortness of breath, muscle cramps, fatigue, dizziness, confusion, or irregular heart rhythm, be sure to seek immediate medical attention, as they may indicate potential kidney damage.
Additionally, beta-blockers such as Lopressor work by lowering both blood pressure and heart rate (via the Cleveland Clinic). Like ACE inhibitors, mixing beta-blockers with ibuprofen also diminishes their blood pressure-lowering efficacy. According to Drugs.com, one potential explanation is that ibuprofen may cause fluid retention, which can put additional strain on the heart and blood vessels, resulting in higher blood pressure levels.